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KMID : 0613820130230091073
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Journal of Life Science
2013 Volume.23 No. 9 p.1073 ~ p.1078
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Antioxidant and Anti-inflammatory Effects of Bletilla striata Reichenbach fil. Fractions as Cosmetic
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Yoon Ji-Hun
Park Seong-Geun
Lee Mi-Ji
Park Jin-Young
Seo Kyo-Seong
Woo Kyung-Chul
Lee Chang-Eon
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Abstract
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The antioxidant and anti-inflammatory effects of active ingredients in cosmetics are very important. The effects are closely related to the prevention of skin aging. Among medicinal plants, Bletilla striata Reichenbach fil. has well-known pharmacological activity. Extracted samples were prepared using sequential fractionation of ethyl acetate, butanol, and water. The antioxidant effect of the fractions was confirmed by DPPH and ABTS+ radical scavenging. Among the various fractions of B. striata Reichenbach fil., ethyl acetate was associated with a reduction in nitric oxide production, which was induced by LPS (lipopolysaccharide) treatment in a dose-dependent manner. In addition, the production of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2), which are upstream regulators of nitric oxide production, was also inhibited. Thus, the ethyl acetate fraction of B. striata Reichenbach fil. appears to be a potential active ingredient for use in cosmetics.
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KEYWORD
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Anti-oxidant, Induced-Nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), fraction, Bletilla striata Reichenbach fil.
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